Bioadhesive hydrogel microenvironments to modulate epithelial morphogenesis
نویسندگان
چکیده
منابع مشابه
Bioadhesive hydrogel microenvironments to modulate epithelial morphogenesis.
Epithelial cells polarize and differentiate into organotypic cell aggregates in response to cell-cell and cell-matrix interactions. For example, Madin-Darby Canine Kidney (MDCK) cells form spherical cell aggregates (cysts) with distinct apical and basolateral polarity when cultured three dimensionally (embedded) in type I collagen gels. To investigate the effects of individual extracellular fac...
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Bioengineered hydrogels have been explored in cell and tissue engineering applications to support cell growth and modulate its behavior. A rationally designed scaffold should allow for encapsulated cells to survive, adhere, proliferate, remodel the niche, and can be used for controlled delivery of biomolecules. Here we report a microarray of composite bioadhesive microgels with modular dimensio...
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ژورنال
عنوان ژورنال: Biomaterials
سال: 2008
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2008.03.008